Progression of Extrapyramidal Signs in Alzheimer’s Disease: Clinical and Neuropathological Correlates

Progression of Extrapyramidal Signs in Alzheimer's Disease: Clinical and Neuropathological Correlates.

BACKGROUND Extrapyramidal signs (EPS) are frequent in Alzheimer's disease (AD) and core manifestation of related diseases, i.e., dementia with Lewy bodies and Parkinson's disease; furthermore, Lewy bodies and AD-type pathology occur in all three conditions. OBJECTIVE To identify clusters of EPS progression over time and their clinical and neuropathological correlates. METHODS 3,502 AD patie...

Clinical and MR correlates in children with extrapyramidal cerebral palsy.

PURPOSE To identify the characteristic MR findings in extrapyramidal cerebral palsy. METHOD Six patients who had suffered intrapartum asphyxia and who subsequently developed extrapyramidal cerebral palsy were identified. Asphyxia was evidenced by severe neonatal systemic acidosis as documented by a venous cord pH of less than 7.0 whenever available, or acidosis in subsequent arterial blood ga...

Clinical and multimodal biomarker correlates of ADNI neuropathological findings

BACKGROUND Autopsy series commonly report a high percentage of coincident pathologies in demented patients, including patients with a clinical diagnosis of dementia of the Alzheimer type (DAT). However many clinical and biomarker studies report cases with a single neurodegenerative disease. We examined multimodal biomarker correlates of the consecutive series of the first 22 Alzheimer's Disease...

Cognitive Impairments in Siblings of Alzheimers Disease Patients: Possible Preclinical Signs of the Disease

Extrapyramidal signs in cognitively intact elderly people.

AIM to investigate the prevalence of extrapyramidal signs in elderly people and their relationship to disease. SETTING AND SUBJECTS 151 non-demented subjects age 65 and over living within a defined geographical area in Nottingham who were participating in the MRC multicentre Cognitive Function and Ageing Study. MEASUREMENTS subjects were assessed at home. Extrapyramidal signs were rated acc...